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KMID : 0358420160590050397
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Korean Journal of Obstetrics and Gynecology
2016 Volume.59 No. 5 p.397 ~ p.402
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Hepatic infarction in a pregnant woman with antiphospholipid syndrome and triple antibody positivity: A case report focusing on catastrophic antiphospholipid syndrome
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Kim Ji-Hye
Yee Cheong-A
Kuk Jin-Yi
Choi Suk-Joo
Oh Soo-Young
Roh Cheong-Rae
Kim Jong-Hwa
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Abstract
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Pregnant women with antiphospholipid syndrome (APS) carry a high risk of arterial or venous thrombosis. Such thrombotic conditions occur more frequently in patients with triple positivity to antiphospholipid antibodies or with high antibody titers. Hepatic infarction is a rare complication in pregnant women with APS, and it sometimes mimics HELLP syndrome. This report describes a preeclamptic pregnant woman with APS who had high titers of three antiphospholipid antibodies. She experienced severe epigastric pain with elevated liver enzymes; in addition, she had tachycardia and tachypnea. The clinical findings suggested hepatic infarction and pulmonary thromboembolism, a partial manifestation of catastrophic APS. Therefore, she underwent emergent cesarean section at 25+2 weeks of gestation. After the delivery, her laboratory test indicated HELLP-like features, and computed tomography confirmed hepatic infarction and pulmonary micro-thromboembolism. Here, we report a case of a partial manifestation of catastrophic APS in a pregnant woman with triple antibody positivity, including a brief literature review.
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KEYWORD
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Antiphospholipid antibodies, Catastrophic antiphospholipid syndrome, HELLP syndrome, Hepatic infarction, Triple antibody positivity
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